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While reduced-rely MBL rarely progresses to CLL, large-rely MBL progresses to CLL demanding therapy at a amount of one% to two% a year. High-depend MBL is distinguished from Rai 0 CLL based on whether the B-cell count is higher than or underneath five × 109/L. Whilst people today with equally superior-rely MBL and CLL Rai phase 0 are at enhanced t